CYP19A1

GENE INFORMATION

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Gene name

CYP19A1 (HGNC Symbol)

Synonyms

ARO, ARO1, aromatase, CPV1, CYAR, CYP19, P-450AROM

Description

Cytochrome P450, family 19, subfamily A, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

15

Cytoband

q21.2

Chromosome location (bp)

51208057 - 51338610

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137869 (version 78.38)

Entrez gene

1588

UniProt

P11511 (UniProt - Evidence at protein level)

neXtProt

NX_P11511

Antibodypedia

CYP19A1 antibodies
 

PROTEIN VIEW

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CYP19A1-001
 
CYP19A1-002
 
CYP19A1-004
 
CYP19A1-007
 
CYP19A1-008
 
CYP19A1-012
 
CYP19A1-013
 
CYP19A1-014
 
CYP19A1-015
 
CYP19A1-016
 
CYP19A1-017
 
CYP19A1-020
 
CYP19A1-201
 
CYP19A1-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP19A1-001 ENSP00000379683
ENST00000396402
P11511
Show all »
Show » Show » 503 57.9 No 2
CYP19A1-002 ENSP00000452872
ENST00000559980
H0YKN1
Show all »
Show » Show » 172 19.3 No 0
CYP19A1-004 ENSP00000383930
ENST00000405913
P11511
Show all »
Show » Show » 218 24.5 No 0
CYP19A1-007 ENSP00000379685
ENST00000396404
P11511
Show all »
Show » Show » 503 57.9 No 2
CYP19A1-008 ENSP00000391139
ENST00000453807
E7EPL6
Show all »
Show » Show » 242 27.5 No 0
CYP19A1-012 ENSP00000453318
ENST00000559646
H0YLS2
Show all »
Show » Show » 165 18.5 No 0
CYP19A1-013 ENSP00000384389
ENST00000405011
E9PGZ6
Show all »
Show » Show » 166 18.6 No 0
CYP19A1-014 ENSP00000453149
ENST00000559878
P11511
Show all »
Show » Show » 503 57.9 No 1
CYP19A1-015 ENSP00000453280
ENST00000558328
H0YLP1
Show all »
Show » Show » 283 32.3 No 0
CYP19A1-016 ENSP00000452627
ENST00000557858
P11511
Show all »
Show » Show » 218 24.5 No 0
CYP19A1-017 ENSP00000454039
ENST00000561075
H0YNJ7
Show all »
Show » Show » 244 28.1 No 0
CYP19A1-020 ENSP00000452667
ENST00000559653
Show » Show » 138 15.9 No 1
CYP19A1-201 ENSP00000260433
ENST00000260433
P11511
Show all »
Show » Show » 503 57.9 No 2
CYP19A1-202 ENSP00000479587
ENST00000613097
Show » 41 4.9 No 0