STRA6 - Gene info - The Human Protein Atlas

Gene name

STRA6 (HGNC Symbol)

Synonyms

FLJ12541

Description

Stimulated by retinoic acid 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Chromosome

Cytoband

q24.1

Chromosome location (bp)

74179466 - 74212267

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137868 (version 78.38)

Entrez gene

64220

UniProt

Q9BX79 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STRA6-001

ENSP00000378537
ENST00000395105

Q9BX79
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Q9BX79 [Direct mapping]
Stimulated by retinoic acid gene 6 protein homolog
I3L0M6 [Target identity:13%; Query identity:100%]
Stimulated by retinoic acid gene 6 protein homolog {ECO:0000313|Ensembl:ENSP00000458204}

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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001523 [retinoid metabolic process]
GO:0001568 [blood vessel development]
GO:0001822 [kidney development]
GO:0003184 [pulmonary valve morphogenesis]
GO:0003281 [ventricular septum development]
GO:0004872 [receptor activity]
GO:0005886 [plasma membrane]
GO:0007507 [heart development]
GO:0007603 [phototransduction, visible light]
GO:0007612 [learning]
GO:0007631 [feeding behavior]
GO:0016021 [integral component of membrane]
GO:0030324 [lung development]
GO:0030325 [adrenal gland development]
GO:0030540 [female genitalia development]
GO:0042297 [vocal learning]
GO:0043234 [protein complex]
GO:0043583 [ear development]
GO:0043585 [nose morphogenesis]
GO:0048286 [lung alveolus development]
GO:0048520 [positive regulation of behavior]
GO:0048546 [digestive tract morphogenesis]
GO:0048566 [embryonic digestive tract development]
GO:0048589 [developmental growth]
GO:0048745 [smooth muscle tissue development]
GO:0048844 [artery morphogenesis]
GO:0050890 [cognition]
GO:0050905 [neuromuscular process]
GO:0051183 [vitamin transporter activity]
GO:0060322 [head development]
GO:0060323 [head morphogenesis]
GO:0060325 [face morphogenesis]
GO:0060426 [lung vasculature development]
GO:0060539 [diaphragm development]
GO:0060900 [embryonic camera-type eye formation]
GO:0061029 [eyelid development in camera-type eye]
GO:0061038 [uterus morphogenesis]
GO:0061143 [alveolar primary septum development]
GO:0061156 [pulmonary artery morphogenesis]
GO:0061205 [paramesonephric duct development]
GO:0097070 [ductus arteriosus closure]

667

73.5

STRA6-002

ENSP00000326085
ENST00000323940

Q9BX79
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667

73.5

STRA6-003

ENSP00000407176
ENST00000432245

Q9BX79
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Q9BX79 [Direct mapping]
Stimulated by retinoic acid gene 6 protein homolog
I3L0M6 [Target identity:55%; Query identity:100%]
Stimulated by retinoic acid gene 6 protein homolog {ECO:0000313|Ensembl:ENSP00000458204}

Show » « Hide

Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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159

17.2

STRA6-005

ENSP00000456609
ENST00000563965

Q9BX79
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Q9BX79 [Direct mapping]
Stimulated by retinoic acid gene 6 protein homolog
B7Z5G7 [Target identity:99%; Query identity:100%]
cDNA FLJ56406, highly similar to Homo sapiens stimulated by retinoic acid gene 6 homolog (STRA6), mRNA {ECO:0000313|EMBL:BAH12903.1}
I3L0M6 [Target identity:12%; Query identity:100%]
Stimulated by retinoic acid gene 6 protein homolog {ECO:0000313|Ensembl:ENSP00000458204}

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GO:0001523 [retinoid metabolic process]
GO:0001568 [blood vessel development]
GO:0001822 [kidney development]
GO:0003184 [pulmonary valve morphogenesis]
GO:0003281 [ventricular septum development]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007507 [heart development]
GO:0007603 [phototransduction, visible light]
GO:0007612 [learning]
GO:0007631 [feeding behavior]
GO:0016021 [integral component of membrane]
GO:0030324 [lung development]
GO:0030325 [adrenal gland development]
GO:0030540 [female genitalia development]
GO:0034633 [retinol transport]
GO:0042297 [vocal learning]
GO:0042573 [retinoic acid metabolic process]
GO:0043234 [protein complex]
GO:0043583 [ear development]
GO:0043585 [nose morphogenesis]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0048286 [lung alveolus development]
GO:0048520 [positive regulation of behavior]
GO:0048546 [digestive tract morphogenesis]
GO:0048566 [embryonic digestive tract development]
GO:0048589 [developmental growth]
GO:0048745 [smooth muscle tissue development]
GO:0048844 [artery morphogenesis]
GO:0050890 [cognition]
GO:0050905 [neuromuscular process]
GO:0051183 [vitamin transporter activity]
GO:0060322 [head development]
GO:0060323 [head morphogenesis]
GO:0060325 [face morphogenesis]
GO:0060426 [lung vasculature development]
GO:0060539 [diaphragm development]
GO:0060900 [embryonic camera-type eye formation]
GO:0061029 [eyelid development in camera-type eye]
GO:0061038 [uterus morphogenesis]
GO:0061143 [alveolar primary septum development]
GO:0061156 [pulmonary artery morphogenesis]
GO:0061205 [paramesonephric duct development]
GO:0071939 [vitamin A import]
GO:0097070 [ductus arteriosus closure]

706

77.7

STRA6-007

ENSP00000413012
ENST00000423167

Q9BX79
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658

72.6

STRA6-008

ENSP00000440238
ENST00000535552

Q9BX79
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Q9BX79 [Direct mapping]
Stimulated by retinoic acid gene 6 protein homolog
I3L0M6 [Target identity:12%; Query identity:100%]
Stimulated by retinoic acid gene 6 protein homolog {ECO:0000313|Ensembl:ENSP00000458204}

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704

77.9

STRA6-009

ENSP00000400403
ENST00000416286

J3KQI6
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J3KQI6 [Target identity:100%; Query identity:100%]
Stimulated by retinoic acid gene 6 protein homolog {ECO:0000313|Ensembl:ENSP00000400403}
I3L0M6 [Target identity:13%; Query identity:100%]
Stimulated by retinoic acid gene 6 protein homolog {ECO:0000313|Ensembl:ENSP00000458204}

Show » « Hide

Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004872 [receptor activity]
GO:0051180 [vitamin transport]
GO:0051183 [vitamin transporter activity]

659

72.6

STRA6-010

ENSP00000410221
ENST00000449139

Q9BX79
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Show » « Hide

667

73.5

STRA6-011

ENSP00000458827
ENST00000574278

Q9BX79
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682

75.2

STRA6-015

ENSP00000458204
ENST00000571341

I3L0M6
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I3L0M6 [Target identity:100%; Query identity:100%]
Stimulated by retinoic acid gene 6 protein homolog {ECO:0000313|Ensembl:ENSP00000458204}

Show » « Hide

Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004872 [receptor activity]
GO:0051183 [vitamin transporter activity]

9.6

STRA6-019

ENSP00000459546
ENST00000572785

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

266

STRA6-201

ENSP00000479112
ENST00000616000

Q9BX79
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667

73.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.