MAP2K5

GENERAL INFORMATION

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Gene name

MAP2K5

Gene description

Mitogen-activated protein kinase kinase 5

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in all tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA027347 , HPA027755 , CAB022094
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MAP2K5 (HGNC Symbol)

Synonyms

HsT17454, MAPKK5, MEK5, PRKMK5

Description

Mitogen-activated protein kinase kinase 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

Chromosome

15

Cytoband

q23

Chromosome location (bp)

67542709 - 67807123

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137764 (version 78.38)

Entrez gene

5607

UniProt

Q13163 (UniProt - Evidence at protein level)

neXtProt

NX_Q13163

Antibodypedia

MAP2K5 antibodies


PROTEIN BROWSER

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ENST00000178640
 
ENST00000340972
 
ENST00000354498
 
ENST00000395476
 
ENST00000439036
 
ENST00000557869
 
ENST00000559262
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP2K5-001 ENSP00000178640
ENST00000178640
Q13163
Show all »
Show » Show » 448 50.1 No 0
MAP2K5-002 ENSP00000342101
ENST00000340972
A6NK28
Show all »
Show » Show » 258 29.2 No 0
MAP2K5-003 ENSP00000390196
ENST00000439036
H7BZL1
Show all »
Show » Show » 128 14.1 No 0
MAP2K5-005 ENSP00000346493
ENST00000354498
Q13163
Show all »
Show » Show » 412 46.1 No 0
MAP2K5-006 ENSP00000480580
ENST00000559262
Show » Show » 182 20.1 No 0
MAP2K5-009 ENSP00000483771
ENST00000557869
Show » 49 5.6 No 0
MAP2K5-013 ENSP00000378859
ENST00000395476
Q13163
Show all »
Show » Show » 438 49 No 0