NUMA1

GENERAL INFORMATION

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Gene name

NUMA1

Gene description

Nuclear mitotic apparatus protein 1

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

23
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

High nuclear expression in all tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA019841 , HPA019859 , HPA029912
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

NUMA1

Synonyms

Description

Nuclear mitotic apparatus protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Chromosome

11

Cytoband

q13.4

Chromosome location (bp)

72002864 - 72080693

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137497 (version 78.38)

Entrez gene

4926

UniProt

Q14980 (UniProt - Evidence at protein level)

neXtProt

NX_Q14980

Antibodypedia

NUMA1 antibodies


PROTEIN BROWSER

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ENST00000351960
 
ENST00000358965
 
ENST00000366394
 
ENST00000368959
 
ENST00000393695
 
ENST00000535087
 
ENST00000535111
 
ENST00000535838
 
ENST00000535947
 
ENST00000537217
 
ENST00000537930
 
ENST00000541584
 
ENST00000541641
 
ENST00000541719
 
ENST00000542977
 
ENST00000543009
 
ENST00000543937
 
ENST00000544129
 
ENST00000544238
 
ENST00000546131
 
ENST00000613205
 
ENST00000616538
 
ENST00000620566
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NUMA1-001 ENSP00000377298
ENST00000393695
Q14980
Show all »
Show » Show » 2115 238.3 No 0
NUMA1-002 ENSP00000351851
ENST00000358965
Q14980
Show all »
Show » Show » 2101 236.5 No 0
NUMA1-005 ENSP00000442936
ENST00000537217
F5H6Y5
Show all »
Show » Show » 691 78.3 No 0
NUMA1-006 ENSP00000260051
ENST00000351960
Q14980
Show all »
Show » Show » 979 109.3 No 0
NUMA1-009 ENSP00000444880
ENST00000542977
F5H4J1
Show all »
Show » Show » 852 97.1 No 0
NUMA1-012 ENSP00000440954
ENST00000541584
Q96HN5
Show all »
Show » Show » 964 107.3 No 0
NUMA1-014 ENSP00000441598
ENST00000541641
F5GWK2
Show all »
Show » Show » 72 8.1 No 0
NUMA1-015 ENSP00000439759
ENST00000543937
F5H0Z7
Show all »
Show » Show » 201 22.5 No 0
NUMA1-017 ENSP00000357955
ENST00000368959
F8W6T3
Show all »
Show » Show » 91 10.1 No 0
NUMA1-018 ENSP00000442331
ENST00000546131
F5H7R5
Show all »
Show » Show » 56 6.2 No 0
NUMA1-019 ENSP00000441674
ENST00000535111
F5GWA2
Show all »
Show » Show » 61 6.8 No 0
NUMA1-020 ENSP00000438331
ENST00000541719
F5H068
Show all »
Show » Show » 83 9.3 No 0
NUMA1-021 ENSP00000438318
ENST00000366394
F5H073
Show all »
Show » Show » 75 8.5 No 0
NUMA1-022 ENSP00000444831
ENST00000535838
F5H4Y4
Show all »
Show » Show » 59 6.5 No 0
NUMA1-023 ENSP00000439576
ENST00000535087
F5H1L0
Show all »
Show » Show » 109 12.2 No 0
NUMA1-024 ENSP00000438821
ENST00000543009
F5H3L6
Show all »
Show » Show » 174 19.6 No 0
NUMA1-025 ENSP00000438589
ENST00000537930
F5H2F3
Show all »
Show » Show » 159 18 No 0
NUMA1-026 ENSP00000442761
ENST00000544238
F5H763
Show all »
Show » Show » 220 24.7 No 0
NUMA1-027 ENSP00000444175
ENST00000535947
F5GZW1
Show all »
Show » Show » 146 16.6 No 0
NUMA1-028 ENSP00000439092
ENST00000544129
F5H2F3
Show all »
Show » Show » 159 18 No 0
NUMA1-201 ENSP00000480172
ENST00000613205
Q14980
Show all »
Show » Show » 979 109.3 No 0
NUMA1-202 ENSP00000481541
ENST00000616538
F5H4J1
Show all »
Show » Show » 2099 236.2 No 0
NUMA1-203 ENSP00000478624
ENST00000620566
Q14980
Show all »
Show » Show » 2101 236.5 No 0