MYO7A

GENE INFORMATION

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Gene name

MYO7A (HGNC Symbol)

Synonyms

DFNA11, DFNB2, NSRD2, USH1B

Description

Myosin VIIA (HGNC Symbol)

Entrez gene summary

This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q13.5

Chromosome location (bp)

77128264 - 77215239

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137474 (version 78.38)

Entrez gene

4647

UniProt

Q13402 (UniProt - Evidence at protein level)

neXtProt

NX_Q13402

Antibodypedia

MYO7A antibodies
 

PROTEIN VIEW

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MYO7A-001
 
MYO7A-002
 
MYO7A-005
 
MYO7A-009
 
MYO7A-010
 
MYO7A-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYO7A-001 ENSP00000386331
ENST00000409709
Q13402
Show all »
Show » Show » 2215 254.4 No 0
MYO7A-002 ENSP00000392185
ENST00000458637
Q13402
Show all »
Show » Show » 2175 250.2 No 0
MYO7A-005 ENSP00000386689
ENST00000409893
B9A012
Show all »
Show » Show » 1178 135.8 No 0
MYO7A-009 ENSP00000386635
ENST00000409619
Q13402
Show all »
Show » Show » 2166 249.2 No 0
MYO7A-010 ENSP00000417017
ENST00000458169
H7C4D8
Show all »
Show » Show » 1357 155.9 No 0
MYO7A-201 ENSP00000477640
ENST00000620575
Show » Show » 1198 138.1 No 0