TFAP2A

GENERAL INFORMATION

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Gene name

TFAP2A

Gene description

Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (placenta, skin)
GTEx:Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein localization

Selective nuclear expression in trophoblastic cells and squamous epithelia.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 3 antibodies.
HPA028850 , HPA056871 , CAB000326
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (placenta, skin)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (skin)

Organ

Expression



GENE INFORMATION

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Gene name

TFAP2A (HGNC Symbol)

Synonyms

AP-2, AP2TF, TFAP2

Description

Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

Chromosome

6

Cytoband

p24.3

Chromosome location (bp)

10393186 - 10419659

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137203 (version 78.38)

Entrez gene

7020

UniProt

P05549 (UniProt - Evidence at protein level)

neXtProt

NX_P05549

Antibodypedia

TFAP2A antibodies


PROTEIN BROWSER

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ENST00000319516
 
ENST00000379604
 
ENST00000379608
 
ENST00000379613
 
ENST00000461628
 
ENST00000465858
 
ENST00000466073
 
ENST00000475264
 
ENST00000482890
 
ENST00000498450
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TFAP2A-001 ENSP00000368933
ENST00000379613
Q96SH1
Show all »
Show » Show » 439 48.3 No 0
TFAP2A-003 ENSP00000316516
ENST00000319516
P05549
Show all »
Show » Show » 433 47.4 No 0
TFAP2A-005 ENSP00000368928
ENST00000379608
P05549
Show all »
Show » Show » 431 47.2 No 0
TFAP2A-007 ENSP00000418541
ENST00000482890
P05549
Show all »
Show » Show » 437 48.1 No 0
TFAP2A-009 ENSP00000419961
ENST00000498450
C9JXZ2
Show all »
Show » Show » 136 14.7 No 0
TFAP2A-010 ENSP00000417495
ENST00000466073
C1K3N0
Show all »
Show » Show » 328 35.9 No 0
TFAP2A-016 ENSP00000418391
ENST00000465858
C9J6N8
Show all »
Show » Show » 173 19 No 0
TFAP2A-017 ENSP00000417735
ENST00000461628
Show » 81 8.7 No 0
TFAP2A-018 ENSP00000419696
ENST00000475264
Show » 218 23.6 No 0
TFAP2A-201 ENSP00000368924
ENST00000379604
P05549
Show all »
Show » Show » 437 48.1 No 0