DERL1

GENE INFORMATION

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Gene name

DERL1 (HGNC Symbol)

Synonyms

DER-1, DER1, derlin-1, FLJ13784, MGC3067, PRO2577

Description

Derlin 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Chromosome

8

Cytoband

q24.13

Chromosome location (bp)

123013164 - 123042423

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136986 (version 78.38)

Entrez gene

79139

UniProt

Q9BUN8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BUN8

Antibodypedia

DERL1 antibodies
 

PROTEIN VIEW

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DERL1-001
 
DERL1-002
 
DERL1-004
 
DERL1-005
 
DERL1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DERL1-001 ENSP00000259512
ENST00000259512
Q9BUN8
Show all »
Show » Show » 251 28.8 No 4
DERL1-002 ENSP00000389965
ENST00000419562
B4E1G1
Show all »
Show » Show » 151 17 No 2
DERL1-004 ENSP00000384289
ENST00000405944
Q9BUN8
Show all »
Show » Show » 231 26.4 No 4
DERL1-005 ENSP00000429199
ENST00000523036
E5RGY0
Show all »
Show » Show » 151 17.2 No 2
DERL1-006 ENSP00000430086
ENST00000519018
E5RGY0
Show all »
Show » Show » 151 17.2 No 2