GABBR2

GENE INFORMATION

? »

Gene name

GABBR2 (HGNC Symbol)

Synonyms

GABABR2, GPR51, GPRC3B, HG20

Description

Gamma-aminobutyric acid (GABA) B receptor, 2 (HGNC Symbol)

Entrez gene summary

The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]

Chromosome

9

Cytoband

q22.33

Chromosome location (bp)

98288109 - 98709197

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136928 (version 78.38)

Entrez gene

9568

UniProt

O75899 (UniProt - Evidence at protein level)

neXtProt

NX_O75899

Antibodypedia

GABBR2 antibodies
 

PROTEIN VIEW

? »
 
 
 
GABBR2-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GABBR2-001 ENSP00000259455
ENST00000259455
O75899
Show all »
Show » Show » 941 105.8 Yes 7