IL10

GENE INFORMATION

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Gene name

IL10 (HGNC Symbol)

Synonyms

CSIF, IL-10, IL10A, TGIF

Description

Interleukin 10 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

Chromosome

1

Cytoband

q32.1

Chromosome location (bp)

206767602 - 206772494

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136634 (version 78.38)

Entrez gene

3586

UniProt

P22301 (UniProt - Evidence at protein level)

neXtProt

NX_P22301

Antibodypedia

IL10 antibodies
 

PROTEIN VIEW

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IL10-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL10-001 ENSP00000412237
ENST00000423557
P22301
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