ACTL6A

GENE INFORMATION

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Gene name

ACTL6A (HGNC Symbol)

Synonyms

Actl6, Arp4, BAF53A, INO80K

Description

Actin-like 6A (HGNC Symbol)

Entrez gene summary

This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q26.33

Chromosome location (bp)

179562880 - 179588408

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136518 (version 78.38)

Entrez gene

86

UniProt

O96019 (UniProt - Evidence at protein level)

neXtProt

NX_O96019

Antibodypedia

ACTL6A antibodies
 

PROTEIN VIEW

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ACTL6A-001
 
ACTL6A-002
 
ACTL6A-009
 
ACTL6A-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACTL6A-001 ENSP00000397552
ENST00000429709
O96019
Show all »
Show » Show » 429 47.5 No 0
ACTL6A-002 ENSP00000394014
ENST00000450518
O96019
Show all »
Show » Show » 387 43.2 No 0
ACTL6A-009 ENSP00000420153
ENST00000490364
C9JQT2
Show all »
Show » 50 5.5 No 0
ACTL6A-201 ENSP00000376430
ENST00000392662
O96019
Show all »
Show » Show » 387 43.2 No 0