PNPLA8

GENERAL INFORMATION

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Gene name

PNPLA8

Gene description

Patatin-like phospholipase domain containing 8

Protein class

Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA020083
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PNPLA8 (HGNC Symbol)

Synonyms

IPLA2-2, IPLA2G, iPLA2gamma

Description

Patatin-like phospholipase domain containing 8 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. A pseudogene of this gene is located on the X chromosome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

7

Cytoband

q31.1

Chromosome location (bp)

108470422 - 108569666

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135241 (version 78.38)

Entrez gene

50640

UniProt

Q9NP80 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NP80

Antibodypedia

PNPLA8 antibodies


PROTEIN BROWSER

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ENST00000257694
 
ENST00000415498
 
ENST00000422087
 
ENST00000426128
 
ENST00000427008
 
ENST00000436062
 
ENST00000453085
 
ENST00000453144
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PNPLA8-001 ENSP00000257694
ENST00000257694
Q9NP80
Show all »
Show » Show » 782 88.5 No 1
PNPLA8-002 ENSP00000410804
ENST00000422087
Q9NP80
Show all »
Show » Show » 782 88.5 No 1
PNPLA8-003 ENSP00000406779
ENST00000436062
Q9NP80
Show all »
Show » Show » 782 88.5 No 1
PNPLA8-004 ENSP00000387789
ENST00000453144
Q9NP80
Show all »
Show » Show » 682 77 No 1
PNPLA8-005 ENSP00000402274
ENST00000453085
Q9NP80
Show all »
Show » Show » 639 71.9 No 1
PNPLA8-006 ENSP00000394988
ENST00000426128
Q9NP80
Show all »
Show » Show » 720 81.6 No 1
PNPLA8-007 ENSP00000391872
ENST00000415498
C9J9W9
Show all »
Show » 55 6.6 No 0
PNPLA8-009 ENSP00000406033
ENST00000427008
C9JAX4
Show all »
Show » 193 22.1 No 0