APLNR

GENE INFORMATION

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Gene name

APLNR (HGNC Symbol)

Synonyms

AGTRL1, APJ, APJR, FLJ90771

Description

Apelin receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]

Chromosome

11

Cytoband

q12.1

Chromosome location (bp)

57233577 - 57237314

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134817 (version 78.38)

Entrez gene

187

UniProt

P35414 (UniProt - Evidence at protein level)

neXtProt

NX_P35414

Antibodypedia

APLNR antibodies
 

PROTEIN VIEW

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APLNR-004
 
APLNR-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APLNR-004 ENSP00000475344
ENST00000606794
P35414
Show all »
Show » Show » 380 42.7 No 7
APLNR-201 ENSP00000477818
ENST00000611099
P35414
Show all »
Show » Show » 380 42.7 No 7