DOCK2

GENE INFORMATION

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Gene name

DOCK2 (HGNC Symbol)

Synonyms

KIAA0209

Description

Dedicator of cytokinesis 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]

Chromosome

5

Cytoband

q35.1

Chromosome location (bp)

169637247 - 170083382

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134516 (version 78.38)

Entrez gene

1794

UniProt

Q92608 (UniProt - Evidence at protein level)

neXtProt

NX_Q92608

Antibodypedia

DOCK2 antibodies
 

PROTEIN VIEW

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DOCK2-001
 
DOCK2-004
 
DOCK2-015
 
DOCK2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DOCK2-001 ENSP00000256935
ENST00000256935
Q92608
Show all »
Show » Show » 1830 211.9 No 0
DOCK2-004 ENSP00000429283
ENST00000520908
E7ERW7
Show all »
Show » Show » 1322 153.4 No 0
DOCK2-015 ENSP00000428841
ENST00000519628
H0YB76
Show all »
Show » Show » 161 18.7 No 0
DOCK2-201 ENSP00000438827
ENST00000540750
Show » 335 38.3 No 0