Tissue expression of CCNH - Summary - The Human Protein Atlas

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CCNH

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	CCNH
Gene description	Cyclin H
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in several tissues.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Data reliability	Uncertain based on 1 antibody. CAB019416
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	CCNH (HGNC Symbol)
Synonyms	CycH, p34, p37
Description	Cyclin H (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010]
Chromosome	5
Cytoband	q14.3
Chromosome location (bp)	87391494 - 87413019
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134480 (version 78.38)
Entrez gene	902
UniProt	P51946 (UniProt - Evidence at protein level)
neXtProt	NX_P51946
Antibodypedia	CCNH antibodies

PROTEIN BROWSER

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ENST00000256897		ENST00000504878		ENST00000508855

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
CCNH-001	ENSP00000256897 ENST00000256897	P51946 Show all » « Hide P51946 [Direct mapping] Cyclin-H D6RHI7 [Target identity:77%; Query identity:100%] Uncharacterized protein {ECO:0000313\|Ensembl:ENSP00000426075}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000718 [nucleotide-excision repair, DNA damage removal] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005675 [holo TFIIH complex] GO:0006200 [ATP catabolic process] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006361 [transcription initiation from RNA polymerase I promoter] GO:0006362 [transcription elongation from RNA polymerase I promoter] GO:0006363 [termination of RNA polymerase I transcription] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006370 [7-methylguanosine mRNA capping] GO:0006468 [protein phosphorylation] GO:0008094 [DNA-dependent ATPase activity] GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016591 [DNA-directed RNA polymerase II, holoenzyme] GO:0019901 [protein kinase binding] GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050434 [positive regulation of viral transcription] GO:0051726 [regulation of cell cycle] GO:0070985 [TFIIK complex]	323	37.6	No
CCNH-002	ENSP00000426075 ENST00000504878	D6RHI7 Show all » « Hide D6RHI7 [Target identity:100%; Query identity:100%] Uncharacterized protein {ECO:0000313\|Ensembl:ENSP00000426075}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016591 [DNA-directed RNA polymerase II, holoenzyme] GO:0019901 [protein kinase binding] GO:0051726 [regulation of cell cycle] GO:0070985 [TFIIK complex]	249	28.9	No
CCNH-003	ENSP00000426454 ENST00000508855	D6RG18 Show all » « Hide D6RG18 [Target identity:100%; Query identity:100%] Cyclin-H {ECO:0000313\|Ensembl:ENSP00000426454} Q59FW7 [Target identity:100%; Query identity:93%] Cyclin H variant {ECO:0000313\|EMBL:BAD92579.1}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016591 [DNA-directed RNA polymerase II, holoenzyme] GO:0019901 [protein kinase binding] GO:0051726 [regulation of cell cycle] GO:0070985 [TFIIK complex]	255	29.5	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx