GSTM3

GENE INFORMATION

? »

Gene name

GSTM3 (HGNC Symbol)

Synonyms

GST5

Description

Glutathione S-transferase mu 3 (brain) (HGNC Symbol)

Entrez gene summary

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Chromosome

1

Cytoband

p13.3

Chromosome location (bp)

109733932 - 109741038

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134202 (version 78.38)

Entrez gene

2947

UniProt

P21266 (UniProt - Evidence at protein level)

neXtProt

NX_P21266

Antibodypedia

GSTM3 antibodies
 

PROTEIN VIEW

? »
 
 
 
GSTM3-001
 
GSTM3-201
 
GSTM3-202
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GSTM3-001 ENSP00000354357
ENST00000361066
P21266
Show all »
Show » Show » 225 26.6 No 0
GSTM3-201 ENSP00000256594
ENST00000256594
P21266
Show all »
Show » Show » 225 26.6 No 0
GSTM3-202 ENSP00000444978
ENST00000540225
Show » Show » 212 24.9 No 0