GSTM5

GENE INFORMATION

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Gene name

GSTM5

Synonyms

Description

Glutathione S-transferase mu 5 (HGNC Symbol)

Entrez gene summary

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p13.3

Chromosome location (bp)

109712255 - 109775428

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134201 (version 78.38)

Entrez gene

2949

UniProt

P46439 (UniProt - Evidence at protein level)

neXtProt

NX_P46439

Antibodypedia

GSTM5 antibodies
 

PROTEIN VIEW

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GSTM5-001
 
GSTM5-002
 
GSTM5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GSTM5-001 ENSP00000256593
ENST00000256593
P46439
Show all »
Show » Show » 218 25.7 No 0
GSTM5-002 ENSP00000358828
ENST00000369813
Q5T8Q9
Show all »
Show » Show » 202 23.4 No 0
GSTM5-201 ENSP00000358827
ENST00000369812
Show » Show » 218 25.7 No 0