CASP9

GENERAL INFORMATION

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Gene name

CASP9

Gene description

Caspase 9, apoptosis-related cysteine peptidase

Protein class

Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 3 antibodies.
HPA001473 , HPA046488 , CAB004348
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CASP9 (HGNC Symbol)

Synonyms

APAF-3, ICE-LAP6, MCH6, PPP1R56

Description

Caspase 9, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Chromosome

1

Cytoband

p36.21

Chromosome location (bp)

15490832 - 15526534

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132906 (version 78.38)

Entrez gene

842

UniProt

P55211 (UniProt - Evidence at protein level)

neXtProt

NX_P55211

Antibodypedia

CASP9 antibodies


PROTEIN BROWSER

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ENST00000333868
 
ENST00000348549
 
ENST00000375890
 
ENST00000424908
 
ENST00000440484
 
ENST00000447522
 
ENST00000469637
 
ENST00000546424
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP9-001 ENSP00000330237
ENST00000333868
P55211
Show all »
Show » Show » 416 46.3 No 0
CASP9-002 ENSP00000255256
ENST00000348549
P55211
Show all »
Show » Show » 266 30.2 No 0
CASP9-003 ENSP00000396540
ENST00000447522
Q5JRU2
Show all »
Show » Show » 266 28.8 No 0
CASP9-004 ENSP00000480785
ENST00000469637
Show » 47 5.4 No 0
CASP9-005 ENSP00000411304
ENST00000440484
Q5JRU8
Show all »
Show » Show » 254 28.4 No 0
CASP9-007 ENSP00000408691
ENST00000424908
Show » Show » 198 21.8 No 0
CASP9-008 ENSP00000365051
ENST00000375890
P55211
Show all »
Show » Show » 333 36.6 No 0
CASP9-009 ENSP00000449584
ENST00000546424
F8VVS7
Show all »
Show » Show » 421 46.5 No 0