LPIN3

GENERAL INFORMATION

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Gene name

LPIN3

Gene description

Lipin 3

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in a subset of tissues including lymphoid tissues, Leydig cells and epididymis.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA051466 , HPA052667
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

LPIN3 (HGNC Symbol)

Synonyms

LIPN3L, SMP2

Description

Lipin 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

20

Cytoband

q12

Chromosome location (bp)

41340920 - 41360582

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132793 (version 78.38)

Entrez gene

64900

UniProt

Q9BQK8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BQK8

Antibodypedia

LPIN3 antibodies


PROTEIN BROWSER

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ENST00000373257
 
ENST00000445975
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LPIN3-001 ENSP00000362354
ENST00000373257
Q9BQK8
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Show » Show » 851 93.6 No 0
LPIN3-003 ENSP00000398092
ENST00000445975
Show » 270 29.9 No 0