ARHGEF11

GENE INFORMATION

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Gene name

ARHGEF11 (HGNC Symbol)

Synonyms

GTRAP48, KIAA0380, PDZ-RHOGEF

Description

Rho guanine nucleotide exchange factor (GEF) 11 (HGNC Symbol)

Entrez gene summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q23.1

Chromosome location (bp)

156934840 - 157045370

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132694 (version 78.38)

Entrez gene

9826

UniProt

O15085 (UniProt - Evidence at protein level)

neXtProt

NX_O15085

Antibodypedia

ARHGEF11 antibodies
 

PROTEIN VIEW

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ARHGEF11-001
 
ARHGEF11-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARHGEF11-001 ENSP00000357177
ENST00000368194
O15085
Show all »
Show » Show » 1562 172.2 No 0
ARHGEF11-002 ENSP00000354644
ENST00000361409
O15085
Show all »
Show » Show » 1522 167.7 No 0