DAP3

GENE INFORMATION

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Gene name

DAP3 (HGNC Symbol)

Synonyms

bMRP-10, DAP-3, DKFZp686G12159, MGC126058, MGC126059, MRP-S29, MRPS29

Description

Death associated protein 3 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]

Chromosome

1

Cytoband

q22

Chromosome location (bp)

155687960 - 155739010

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132676 (version 78.38)

Entrez gene

7818

UniProt

P51398 (UniProt - Evidence at protein level)

neXtProt

NX_P51398

Antibodypedia

DAP3 antibodies
 

PROTEIN VIEW

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DAP3-001
 
DAP3-002
 
DAP3-003
 
DAP3-004
 
DAP3-007
 
DAP3-009
 
DAP3-012
 
DAP3-013
 
DAP3-014
 
DAP3-016
 
DAP3-018
 
DAP3-021
 
DAP3-022
 
DAP3-023
 
DAP3-024
 
DAP3-025
 
DAP3-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DAP3-001 ENSP00000357320
ENST00000368336
P51398
Show all »
Show » Show » 398 45.6 No 0
DAP3-002 ENSP00000341692
ENST00000343043
P51398
Show all »
Show » Show » 398 45.6 No 0
DAP3-003 ENSP00000476899
ENST00000471214
V9GYL9
Show all »
Show » Show » 299 34.3 No 0
DAP3-004 ENSP00000476592
ENST00000471642
P51398
Show all »
Show » Show » 357 41 No 0
DAP3-007 ENSP00000476889
ENST00000465375
V9GYL4
Show all »
Show » 113 12.6 No 0
DAP3-009 ENSP00000476840
ENST00000497826
V9GYJ9
Show all »
Show » Show » 267 30.5 No 0
DAP3-012 ENSP00000476816
ENST00000470830
V9GYJ3
Show all »
Show » Show » 120 14.2 No 0
DAP3-013 ENSP00000476291
ENST00000463575
V9GY11
Show all »
Show » Show » 181 20.8 No 0
DAP3-014 ENSP00000477265
ENST00000479151
Show » 242 27.5 No 0
DAP3-016 ENSP00000476558
ENST00000477394
V9GYF7
Show all »
Show » 210 23.4 No 0
DAP3-018 ENSP00000477453
ENST00000463295
V9GYF7
Show all »
Show » 106 12.1 No 0
DAP3-021 ENSP00000476624
ENST00000475056
V9GYC9
Show all »
Show » 115 12.7 No 0
DAP3-022 ENSP00000477139
ENST00000490249
V9GYW1
Show all »
Show » 140 16 No 0
DAP3-023 ENSP00000476706
ENST00000491777
V9GYF7
Show all »
Show » 45 5.3 No 0
DAP3-024 ENSP00000412605
ENST00000421487
P51398
Show all »
Show » Show » 364 41.7 No 0
DAP3-025 ENSP00000477025
ENST00000608852
V9GYR8
Show all »
Show » 65 7.3 No 0
DAP3-201 ENSP00000445003
ENST00000535183
P51398
Show all »
Show » Show » 357 41 No 0