LGALS3

GENE INFORMATION

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Gene name

LGALS3 (HGNC Symbol)

Synonyms

GALIG, LGALS2, MAC-2

Description

Lectin, galactoside-binding, soluble, 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]

Chromosome

14

Cytoband

q22.3

Chromosome location (bp)

55124110 - 55145413

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131981 (version 78.38)

Entrez gene

3958

UniProt

P17931 (UniProt - Evidence at protein level)

neXtProt

NX_P17931

Antibodypedia

LGALS3 antibodies
 

PROTEIN VIEW

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LGALS3-001
 
LGALS3-003
 
LGALS3-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LGALS3-001 ENSP00000254301
ENST00000254301
P17931
Show all »
Show » Show » 250 26.2 No 0
LGALS3-003 ENSP00000451381
ENST00000554715
G3V3R6
Show all »
Show » Show » 233 24.1 No 0
LGALS3-008 ENSP00000451526
ENST00000553493
G3V407
Show all »
Show » 88 8.3 No 0