UBE2D2

GENE INFORMATION

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Gene name

UBE2D2 (HGNC Symbol)

Synonyms

UBC4, UbcH5B

Description

Ubiquitin-conjugating enzyme E2D 2 (HGNC Symbol)

Entrez gene summary

Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Chromosome

5

Cytoband

q31.2

Chromosome location (bp)

139526431 - 139628433

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131508 (version 78.38)

Entrez gene

7322

UniProt

P62837 (UniProt - Evidence at protein level)

neXtProt

NX_P62837

Antibodypedia

UBE2D2 antibodies
 

PROTEIN VIEW

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UBE2D2-001
 
UBE2D2-002
 
UBE2D2-003
 
UBE2D2-006
 
UBE2D2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UBE2D2-001 ENSP00000381717
ENST00000398733
P62837
Show all »
Show » Show » 147 16.7 No 0
UBE2D2-002 ENSP00000424941
ENST00000505548
P62837
Show all »
Show » Show » 118 13.6 No 0
UBE2D2-003 ENSP00000426523
ENST00000505007
D6RFM0
Show all »
Show » Show » 98 11.1 No 0
UBE2D2-006 ENSP00000429613
ENST00000511725
P62837
Show all »
Show » Show » 118 13.6 No 0
UBE2D2-201 ENSP00000253815
ENST00000253815
D6RFM0
Show all »
Show » Show » 147 16.7 No 0