RAMP2

GENE INFORMATION

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Gene name

RAMP2

Synonyms

Description

Receptor (G protein-coupled) activity modifying protein 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q21.2

Chromosome location (bp)

42758447 - 42763041

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131477 (version 78.38)

Entrez gene

10266

UniProt

O60895 (UniProt - Evidence at protein level)

neXtProt

NX_O60895

Antibodypedia

RAMP2 antibodies
 

PROTEIN VIEW

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RAMP2-001
 
RAMP2-002
 
RAMP2-003
 
RAMP2-004
 
RAMP2-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAMP2-001 ENSP00000253796
ENST00000253796
O60895
Show all »
Show » Show » 175 19.6 Yes 1
RAMP2-002 ENSP00000466455
ENST00000587142
O60895
Show all »
Show » Show » 180 20.1 Yes 1
RAMP2-003 ENSP00000465725
ENST00000588576
K7EKQ3
Show all »
Show » 112 12.1 Yes 0
RAMP2-004 ENSP00000467463
ENST00000589683
K7EPN3
Show all »
Show » Show » 100 11.5 No 1
RAMP2-005 ENSP00000466980
ENST00000588928
K7ENJ8
Show all »
Show » Show » 49 5.9 No 0