LATS1

GENE INFORMATION

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Gene name

LATS1 (HGNC Symbol)

Synonyms

WARTS

Description

Large tumor suppressor kinase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012]

Chromosome

6

Cytoband

q25.1

Chromosome location (bp)

149658153 - 149718256

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131023 (version 78.38)

Entrez gene

9113

UniProt

O95835 (UniProt - Evidence at protein level)

neXtProt

NX_O95835

Antibodypedia

LATS1 antibodies
 

PROTEIN VIEW

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LATS1-001
 
LATS1-003
 
LATS1-005
 
LATS1-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LATS1-001 ENSP00000437550
ENST00000543571
O95835
Show all »
Show » Show » 1130 126.9 No 0
LATS1-003 ENSP00000444678
ENST00000392273
O95835
Show all »
Show » Show » 690 76.2 No 0
LATS1-005 ENSP00000253339
ENST00000253339
O95835
Show all »
Show » Show » 1130 126.9 No 0
LATS1-007 ENSP00000441265
ENST00000458696
H0YG09
Show all »
Show » Show » 201 21.4 No 0