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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version.
The Entrez gene identifier for the gene is also given. If any of the protein products of
the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the
neXtProt databases for these proteins are displayed.
There is also a link to the Antibodypedia portal where validation data for antibodies produced by other suppliers
against this gene can be found.
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Gene name |
CYP2E1 (HGNC Symbol) |
Synonyms |
CYP2E |
Description |
Cytochrome P450, family 2, subfamily E, polypeptide 1 (HGNC Symbol) |
Entrez gene summary |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008] |
Chromosome |
10 |
Cytoband |
q26.3 |
Chromosome location (bp) |
133520406 - 133561220 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000130649 (version 78.38) |
Entrez gene |
1571 |
UniProt |
P05181 (UniProt - Evidence at protein level) |
neXtProt |
NX_P05181 |
Antibodypedia |
CYP2E1 antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues
(HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius
(turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant.
The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors
SPOCTOPUS,
SignalP 4.0, and
Phobius) and the number of predicted transmembrane region(s) (according to
MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length
(aa) |
Molecular mass
(kDa) |
Signal peptide
(predicted) |
Transmembrane regions
(predicted)
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| CYP2E1-001 |
ENSP00000440689
ENST00000463117
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P05181
Show all »
« Hide
P05181 [Direct mapping]Cytochrome P450 2E1 Cytochrome P450 2E1, N-terminally processed Q4LBD0 [Target identity:19%; Query identity:100%]Putative cytochrome P450 2E1 {ECO:0000313|EMBL:CAI47002.1} F5H694 [Target identity:17%; Query identity:100%]Cytochrome P450 2E1 {ECO:0000313|Ensembl:ENSP00000437799}
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Enzymes
ENZYME proteins
Oxidoreductases
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
Predicted secreted proteins
Secreted proteins predicted by MDSEC
SignalP predicted secreted proteins
Phobius predicted secreted proteins
SPOCTOPUS predicted secreted proteins
Cancer-related genes
Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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« Hide
GO:0000139 [Golgi membrane] GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006641 [triglyceride metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008202 [steroid metabolic process] GO:0010193 [response to ozone] GO:0010243 [response to organonitrogen compound] GO:0016098 [monoterpenoid metabolic process] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen] GO:0017144 [drug metabolic process] GO:0019825 [oxygen binding] GO:0019899 [enzyme binding] GO:0020037 [heme binding] GO:0031227 [intrinsic component of endoplasmic reticulum membrane] GO:0042493 [response to drug] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0045471 [response to ethanol] GO:0046483 [heterocycle metabolic process] GO:0055114 [oxidation-reduction process]
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493 |
56.8 |
Yes |
0 |
| CYP2E1-007 |
ENSP00000412754
ENST00000421586
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H0Y7H4
Show all »
« Hide
H0Y7H4 [Target identity:100%; Query identity:100%]Cytochrome P450 2E1 {ECO:0000313|Ensembl:ENSP00000412754} Q4LBD0 [Target identity:27%; Query identity:100%]Putative cytochrome P450 2E1 {ECO:0000313|EMBL:CAI47002.1}
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MEMSAT-SVM predicted membrane proteins
SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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« Hide
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356 |
41.3 |
No |
0 |
| CYP2E1-008 |
ENSP00000397299
ENST00000418356
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H0Y593
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« Hide
H0Y593 [Target identity:100%; Query identity:100%]Cytochrome P450 2E1 {ECO:0000313|Ensembl:ENSP00000397299} Q4LBD0 [Target identity:31%; Query identity:100%]Putative cytochrome P450 2E1 {ECO:0000313|EMBL:CAI47002.1}
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« Hide
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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« Hide
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306 |
35.5 |
No |
0 |
| CYP2E1-010 |
ENSP00000437799
ENST00000541261
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F5H694
Show all »
« Hide
F5H694 [Target identity:100%; Query identity:100%]Cytochrome P450 2E1 {ECO:0000313|Ensembl:ENSP00000437799}
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Show »
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MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
Predicted secreted proteins
Secreted proteins predicted by MDSEC
SignalP predicted secreted proteins
Phobius predicted secreted proteins
SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process]
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86 |
9.7 |
Yes |
0 |
| CYP2E1-201 |
ENSP00000252945
ENST00000252945
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P05181
Show all »
« Hide
P05181 [Direct mapping]Cytochrome P450 2E1 Cytochrome P450 2E1, N-terminally processed Q4LBD0 [Target identity:19%; Query identity:100%]Putative cytochrome P450 2E1 {ECO:0000313|EMBL:CAI47002.1} F5H694 [Target identity:17%; Query identity:100%]Cytochrome P450 2E1 {ECO:0000313|Ensembl:ENSP00000437799}
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Show »
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Enzymes
ENZYME proteins
Oxidoreductases
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
Predicted secreted proteins
Secreted proteins predicted by MDSEC
SignalP predicted secreted proteins
Phobius predicted secreted proteins
SPOCTOPUS predicted secreted proteins
Cancer-related genes
Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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493 |
56.8 |
Yes |
0 |
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