PVRL2

GENE INFORMATION

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Gene name

PVRL2 (HGNC Symbol)

Synonyms

CD112, HVEB, PRR2, PVRR2

Description

Poliovirus receptor-related 2 (herpesvirus entry mediator B) (HGNC Symbol)

Entrez gene summary

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.32

Chromosome location (bp)

44846175 - 44889228

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000130202 (version 78.38)

Entrez gene

5819

UniProt

Q92692 (UniProt - Evidence at protein level)

neXtProt

NX_Q92692

Antibodypedia

PVRL2 antibodies
 

PROTEIN VIEW

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PVRL2-001
 
PVRL2-002
 
PVRL2-003
 
PVRL2-005
 
PVRL2-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PVRL2-001 ENSP00000252485
ENST00000252485
Q92692
Show all »
Show » Show » 479 51.4 Yes 1
PVRL2-002 ENSP00000252483
ENST00000252483
Q92692
Show all »
Show » Show » 538 57.7 Yes 1
PVRL2-003 ENSP00000465587
ENST00000591581
Q7Z457
Show all »
Show » Show » 210 22.6 No 0
PVRL2-005 ENSP00000468305
ENST00000592018
Show » 54 6.1 No 0
PVRL2-006 ENSP00000465511
ENST00000585601
K7EK87
Show all »
Show » 56 6.1 No 0