Tissue expression of LBP - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. Don't show this again.

LBP

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	LBP
Gene description	Lipopolysaccharide binding protein
Protein class	Plasma proteins Predicted secreted proteins Transporters
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:	Group enriched (adipose tissue, liver)
GTEx:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein localization

Positivity in plasma and cytoplasmic and membranous expression in glandular cells in gastrointestinal tract and hepatocytes.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Data reliability	Uncertain based on 2 antibodies. HPA001508 , CAB025905
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »

RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression

RNA EXPRESSION OVERVIEW

? »

HPA dataset

RNA tissue category:

Group enriched (adipose tissue, liver)

Organ

Expression

GTEx dataset

RNA tissue category:

Tissue enriched (liver)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	LBP (HGNC Symbol)
Synonyms	BPIFD2
Description	Lipopolysaccharide binding protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
Chromosome	20
Cytoband	q11.23
Chromosome location (bp)	38346356 - 38377023
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129988 (version 78.38)
Entrez gene	3929
UniProt	P18428 (UniProt - Evidence at protein level)
neXtProt	NX_P18428
Antibodypedia	LBP antibodies

PROTEIN BROWSER

? »

ENST00000217407

PROTEIN INFORMATION

? »

Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
LBP-001	ENSP00000217407 ENST00000217407	P18428 Show all » « Hide P18428 [Direct mapping] Lipopolysaccharide-binding protein	Show » « Hide Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001530 [lipopolysaccharide binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002232 [leukocyte chemotaxis involved in inflammatory response] GO:0002281 [macrophage activation involved in immune response] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006953 [acute-phase response] GO:0006968 [cellular defense response] GO:0008228 [opsonization] GO:0008289 [lipid binding] GO:0009986 [cell surface] GO:0015920 [lipopolysaccharide transport] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0032490 [detection of molecule of bacterial origin] GO:0032496 [response to lipopolysaccharide] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0032722 [positive regulation of chemokine production] GO:0032755 [positive regulation of interleukin-6 production] GO:0032757 [positive regulation of interleukin-8 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway] GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process] GO:0043032 [positive regulation of macrophage activation] GO:0044130 [negative regulation of growth of symbiont in host] GO:0045087 [innate immune response] GO:0050829 [defense response to Gram-negative bacterium] GO:0050830 [defense response to Gram-positive bacterium] GO:0060265 [positive regulation of respiratory burst involved in inflammatory response] GO:0070062 [extracellular vesicular exosome] GO:0070891 [lipoteichoic acid binding] GO:0071222 [cellular response to lipopolysaccharide] GO:0071223 [cellular response to lipoteichoic acid] GO:0090023 [positive regulation of neutrophil chemotaxis]	481	53.4	Yes	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx