DAD1

GENE INFORMATION

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Gene name

DAD1 (HGNC Symbol)

Synonyms

OST2

Description

Defender against cell death 1 (HGNC Symbol)

Entrez gene summary

DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q11.2

Chromosome location (bp)

22564905 - 22589269

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129562 (version 78.38)

Entrez gene

1603

UniProt

P61803 (UniProt - Evidence at protein level)

neXtProt

NX_P61803

Antibodypedia

DAD1 antibodies
 

PROTEIN VIEW

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DAD1-002
 
DAD1-004
 
DAD1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DAD1-002 ENSP00000250498
ENST00000250498
P61803
Show all »
Show » Show » 113 12.5 No 3
DAD1-004 ENSP00000440242
ENST00000538631
Show » Show » 78 8.5 No 2
DAD1-005 ENSP00000440821
ENST00000543337
F5GXX5
Show all »
Show » Show » 85 9.6 No 2