CD68

GENE INFORMATION

? »

Gene name

CD68 (HGNC Symbol)

Synonyms

DKFZp686M18236, GP110, LAMP4, macrosialin, SCARD1

Description

CD68 molecule (HGNC Symbol)

Entrez gene summary

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

p13.1

Chromosome location (bp)

7579467 - 7582113

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129226 (version 78.38)

Entrez gene

968

UniProt

P34810 (UniProt - Evidence at protein level)

neXtProt

NX_P34810

Antibodypedia

CD68 antibodies
 

PROTEIN VIEW

? »
 
 
 
CD68-001
 
CD68-002
 
CD68-004
 
CD68-005
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD68-001 ENSP00000250092
ENST00000250092
P34810
Show all »
Show » Show » 354 37.4 Yes 1
CD68-002 ENSP00000369867
ENST00000380498
P34810
Show all »
Show » Show » 327 34.7 Yes 1
CD68-004 ENSP00000462198
ENST00000584180
Show » Show » 121 13.2 No 0
CD68-005 ENSP00000462768
ENST00000584502
J3KT24
Show all »
Show » Show » 181 18.6 Yes 0