LIF

GENERAL INFORMATION

? »

Gene name

LIF

Gene description

Leukemia inhibitory factor

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Tissue enhanced (gallbladder, urinary bladder)
GTEx:Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

Protein localization

Mainly cytoplasmic expression in most tissues.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA018844 , CAB025985
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Tissue enhanced (gallbladder, urinary bladder)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (adipose tissue)

Organ

Expression



GENE INFORMATION

? »

Gene name

LIF (HGNC Symbol)

Synonyms

CDF, DIA, HILDA

Description

Leukemia inhibitory factor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Chromosome

22

Cytoband

q12.2

Chromosome location (bp)

30240447 - 30246851

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128342 (version 78.38)

Entrez gene

3976

UniProt

P15018 (UniProt - Evidence at protein level)

neXtProt

NX_P15018

Antibodypedia

LIF antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000249075
 
ENST00000403987
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LIF-001 ENSP00000249075
ENST00000249075
P15018
Show all »
Show » Show » 202 22 Yes 0
LIF-002 ENSP00000384450
ENST00000403987
P15018
Show all »
Show » Show » 88 9.6 No 0