Tissue expression of POR - Summary - The Human Protein Atlas

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POR

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	POR
Gene description	P450 (cytochrome) oxidoreductase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression of varying intensity.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 2 antibodies. HPA010136 , CAB004372
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	POR (HGNC Symbol)
Synonyms	CYPOR, FLJ26468
Description	P450 (cytochrome) oxidoreductase (HGNC Symbol)
Entrez gene summary	This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q11.23
Chromosome location (bp)	75899200 - 75986855
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127948 (version 78.38)
Entrez gene	5447
UniProt	P16435 (UniProt - Evidence at protein level)
neXtProt	NX_P16435
Antibodypedia	POR antibodies

PROTEIN BROWSER

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ENST00000394893		ENST00000412521		ENST00000414186		ENST00000418341		ENST00000421059		ENST00000426184		ENST00000432753		ENST00000439269		ENST00000439297		ENST00000439963		ENST00000447222		ENST00000449920		ENST00000453773		ENST00000461988

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
POR-001	ENSP00000419970 ENST00000461988	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase Q59ED7 [Target identity:100%; Query identity:99%] Putative uncharacterized protein {ECO:0000313\|EMBL:BAD93111.1} E7EMD0 [Target identity:61%; Query identity:100%] NADPH--cytochrome P450 reductase {ECO:0000313\|Ensembl:ENSP00000412490} C9JQ78 [Target identity:5%; Query identity:100%] NADPH--cytochrome P450 reductase {ECO:0000313\|Ensembl:ENSP00000409881}	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0007584 [response to nutrient] GO:0008941 [nitric oxide dioxygenase activity] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032770 [positive regulation of monooxygenase activity] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071371 [cellular response to gonadotropin stimulus] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process] GO:0090181 [regulation of cholesterol metabolic process] GO:0090346 [cellular organofluorine metabolic process]	680	77	No	1
POR-002	ENSP00000409238 ENST00000412521	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:26%; Query identity:100%] NADPH--cytochrome P450 reductase {ECO:0000313\|Ensembl:ENSP00000409881}	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process]	146	16.4	No	1
POR-003	ENSP00000399327 ENST00000414186	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:22%; Query identity:100%] NADPH--cytochrome P450 reductase {ECO:0000313\|Ensembl:ENSP00000409881}	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process]	172	19.3	No	1
POR-004	ENSP00000389719 ENST00000418341	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:62%; Query identity:100%] NADPH--cytochrome P450 reductase {ECO:0000313\|Ensembl:ENSP00000409881}	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0016020 [membrane] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process]	62	7.1	No	1
POR-006	ENSP00000403494 ENST00000439297	C9JDE2 Show all » « Hide C9JDE2 [Target identity:100%; Query identity:100%] NADPH--cytochrome P450 reductase {ECO:0000313\|Ensembl:ENSP00000403494}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		54	6.1	No	0
POR-009	ENSP00000378355 ENST00000394893	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:6%; Query identity:100%] NADPH--cytochrome P450 reductase {ECO:0000313\|Ensembl:ENSP00000409881}	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process]	633	71.6	No	1
POR-014	ENSP00000393527 ENST00000447222		Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0010181 [FMN binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process]	725	81.6	No	0
POR-015	ENSP00000412490 ENST00000439269	E7EMD0 Show all » « Hide E7EMD0 [Target identity:100%; Query identity:100%] NADPH--cytochrome P450 reductase {ECO:0000313\|Ensembl:ENSP00000412490}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process]	418	47.4	No	0
POR-017	ENSP00000395813 ENST00000453773	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:27%; Query identity:100%] NADPH--cytochrome P450 reductase {ECO:0000313\|Ensembl:ENSP00000409881}	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process]	140	15.8	No	1
POR-018	ENSP00000390540 ENST00000439963	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:20%; Query identity:100%] NADPH--cytochrome P450 reductase {ECO:0000313\|Ensembl:ENSP00000409881}	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process]	188	21.1	No	1
POR-019	ENSP00000409881 ENST00000421059	C9JQ78 Show all » « Hide C9JQ78 [Target identity:100%; Query identity:100%] NADPH--cytochrome P450 reductase {ECO:0000313\|Ensembl:ENSP00000409881}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		39	4.2	No	0
POR-020	ENSP00000389409 ENST00000432753	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:23%; Query identity:100%] NADPH--cytochrome P450 reductase {ECO:0000313\|Ensembl:ENSP00000409881}	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process]	166	18.7	No	1
POR-021	ENSP00000399556 ENST00000449920	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:62%; Query identity:100%] NADPH--cytochrome P450 reductase {ECO:0000313\|Ensembl:ENSP00000409881}	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0016020 [membrane] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process]	62	7.1	No	1
POR-022	ENSP00000400964 ENST00000426184	C9JU80 Show all » « Hide C9JU80 [Target identity:100%; Query identity:100%] NADPH--cytochrome P450 reductase {ECO:0000313\|Ensembl:ENSP00000400964}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005506 [iron ion binding] GO:0010181 [FMN binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process]	108	12	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx