FGFRL1

GENE INFORMATION

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Gene name

FGFRL1

Synonyms

Description

Fibroblast growth factor receptor-like 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

p16.3

Chromosome location (bp)

1009936 - 1026897

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000127418 (version 78.38)

Entrez gene

53834

UniProt

Q8N441 (UniProt - Evidence at protein level)

neXtProt

NX_Q8N441

Antibodypedia

FGFRL1 antibodies
 

PROTEIN VIEW

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FGFRL1-001
 
FGFRL1-004
 
FGFRL1-005
 
FGFRL1-006
 
FGFRL1-007
 
FGFRL1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGFRL1-001 ENSP00000381498
ENST00000398484
Q8N441
Show all »
Show » Show » 504 54.5 Yes 1
FGFRL1-004 ENSP00000425025
ENST00000510644
Q8N441
Show all »
Show » Show » 504 54.5 Yes 1
FGFRL1-005 ENSP00000423091
ENST00000504138
Q8N441
Show all »
Show » Show » 504 54.5 Yes 1
FGFRL1-006 ENSP00000424037
ENST00000507339
D6RBN8
Show all »
Show » Show » 152 16.4 Yes 0
FGFRL1-007 ENSP00000426740
ENST00000512174
D6REM7
Show all »
Show » Show » 80 8.7 Yes 0
FGFRL1-201 ENSP00000264748
ENST00000264748
Q8N441
Show all »
Show » Show » 504 54.5 Yes 1