CANX - Gene info - The Human Protein Atlas

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CANX

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TISSUE

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SUBCELL

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CELL LINE

CANCER

GENE INFORMATION

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Gene name	CANX (HGNC Symbol)
Synonyms	CNX, IP90, P90
Description	Calnexin (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	179678628 - 179730925
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127022 (version 78.38)
Entrez gene	821
UniProt	P27824 (UniProt - Evidence at protein level)
neXtProt	NX_P27824
Antibodypedia	CANX antibodies

PROTEIN VIEW

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CANX-001		CANX-002		CANX-003		CANX-005		CANX-006		CANX-007		CANX-008		CANX-009		CANX-010		CANX-014		CANX-017		CANX-018		CANX-021

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
CANX-001	ENSP00000247461 ENST00000247461	P27824 Show all » « Hide P27824 [Direct mapping] Calnexin D6RDP7 [Target identity:28%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000425246} D6RB85 [Target identity:24%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000424341} D6RAU8 [Target identity:22%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000424745} D6RFL1 [Target identity:22%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000426555} D6RAQ8 [Target identity:18%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421813} D6RHJ3 [Target identity:13%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000426052} D6RFW4 [Target identity:5%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421434}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001948 [glycoprotein binding] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0005790 [smooth endoplasmic reticulum] GO:0005791 [rough endoplasmic reticulum] GO:0005840 [ribosome] GO:0006457 [protein folding] GO:0007568 [aging] GO:0009306 [protein secretion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030246 [carbohydrate binding] GO:0030424 [axon] GO:0032839 [dendrite cytoplasm] GO:0034185 [apolipoprotein binding] GO:0035255 [ionotropic glutamate receptor binding] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0043234 [protein complex] GO:0043687 [post-translational protein modification] GO:0044233 [ER-mitochondrion membrane contact site] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0048488 [synaptic vesicle endocytosis] GO:0051082 [unfolded protein binding] GO:0061077 [chaperone-mediated protein folding] GO:0070062 [extracellular vesicular exosome] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:0072583 [clathrin-mediated endocytosis]	592	67.6	Yes	1
CANX-002	ENSP00000424063 ENST00000504734	P27824 Show all » « Hide P27824 [Direct mapping] Calnexin D6RDP7 [Target identity:28%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000425246} D6RB85 [Target identity:24%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000424341} D6RAU8 [Target identity:22%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000424745} D6RFL1 [Target identity:22%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000426555} D6RAQ8 [Target identity:18%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421813} D6RHJ3 [Target identity:13%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000426052} D6RFW4 [Target identity:5%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421434}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0009306 [protein secretion] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030246 [carbohydrate binding] GO:0043687 [post-translational protein modification] GO:0044233 [ER-mitochondrion membrane contact site] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0048488 [synaptic vesicle endocytosis] GO:0051082 [unfolded protein binding] GO:0070062 [extracellular vesicular exosome] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:0072583 [clathrin-mediated endocytosis]	592	67.6	Yes	1
CANX-003	ENSP00000421107 ENST00000502673	D6RGY2 Show all » « Hide D6RGY2 [Target identity:100%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421107} Q6ZP56 [Target identity:100%; Query identity:94%] cDNA FLJ26480 fis, clone KDN05071, highly similar to Calnexin {ECO:0000313\|EMBL:BAC85269.1} D6RFL1 [Target identity:42%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000426555} D6RFW4 [Target identity:10%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421434}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding]	308	35.2	Yes	0
CANX-005	ENSP00000391646 ENST00000452673	P27824 Show all » « Hide P27824 [Direct mapping] Calnexin D6RDP7 [Target identity:28%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000425246} D6RB85 [Target identity:24%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000424341} D6RAU8 [Target identity:22%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000424745} D6RFL1 [Target identity:22%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000426555} D6RAQ8 [Target identity:18%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421813} D6RHJ3 [Target identity:13%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000426052} D6RFW4 [Target identity:5%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421434}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0009306 [protein secretion] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030246 [carbohydrate binding] GO:0043687 [post-translational protein modification] GO:0044233 [ER-mitochondrion membrane contact site] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0048488 [synaptic vesicle endocytosis] GO:0051082 [unfolded protein binding] GO:0070062 [extracellular vesicular exosome] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:0072583 [clathrin-mediated endocytosis]	592	67.6	Yes	1
CANX-006	ENSP00000424745 ENST00000502296	D6RAU8 Show all » « Hide D6RAU8 [Target identity:100%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000424745} D6RAQ8 [Target identity:79%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421813} D6RHJ3 [Target identity:58%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000426052} D6RFW4 [Target identity:23%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421434}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding]	134	14.8	Yes	0
CANX-007	ENSP00000425246 ENST00000502498	D6RDP7 Show all » « Hide D6RDP7 [Target identity:100%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000425246} D6RB85 [Target identity:85%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000424341} D6RAU8 [Target identity:79%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000424745} D6RAQ8 [Target identity:63%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421813} D6RHJ3 [Target identity:46%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000426052} D6RFW4 [Target identity:19%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421434}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding]	168	18.7	Yes	0
CANX-008	ENSP00000426052 ENST00000507307	D6RHJ3 Show all » « Hide D6RHJ3 [Target identity:98%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000426052} D6RFW4 [Target identity:40%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421434}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding]	79	8.6	Yes	0
CANX-009	ENSP00000421813 ENST00000513246	D6RAQ8 Show all » « Hide D6RAQ8 [Target identity:100%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421813} D6RHJ3 [Target identity:72%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000426052} D6RFW4 [Target identity:29%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421434}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum]	107	11.9	Yes	0
CANX-010	ENSP00000421434 ENST00000509563	D6RFW4 Show all » « Hide D6RFW4 [Target identity:100%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421434}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		32	3.6	Yes	0
CANX-014	ENSP00000424140 ENST00000508787		Show » « Hide SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding]	190	21.4	No	0
CANX-017	ENSP00000426555 ENST00000506654	D6RFL1 Show all » « Hide D6RFL1 [Target identity:100%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000426555}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding]	131	15.2	No	0
CANX-018	ENSP00000424740 ENST00000510810		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding]	170	18.7	No	0
CANX-021	ENSP00000424341 ENST00000514383	D6RB85 Show all » « Hide D6RB85 [Target identity:100%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000424341} D6RAU8 [Target identity:93%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000424745} D6RAQ8 [Target identity:74%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421813} D6RHJ3 [Target identity:54%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000426052} D6RFW4 [Target identity:22%; Query identity:100%] Calnexin {ECO:0000313\|Ensembl:ENSP00000421434}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding]	144	16	Yes	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.