Tissue expression of IRF3 - Summary - The Human Protein Atlas

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IRF3

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	IRF3
Gene description	Interferon regulatory factor 3
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	22
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 2 antibodies. HPA004895 , CAB013018
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	IRF3
Synonyms
Description	Interferon regulatory factor 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49659569 - 49665875
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126456 (version 78.38)
Entrez gene	3661
UniProt	Q14653 (UniProt - Evidence at protein level)
neXtProt	NX_Q14653
Antibodypedia	IRF3 antibodies

PROTEIN BROWSER

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ENST00000309877		ENST00000377135		ENST00000377139		ENST00000442265		ENST00000593337		ENST00000593818		ENST00000593922		ENST00000595034		ENST00000596756		ENST00000596765		ENST00000596822		ENST00000597198		ENST00000598108		ENST00000598808		ENST00000599144		ENST00000599223		ENST00000600022		ENST00000600453		ENST00000600911		ENST00000601291		ENST00000601373		ENST00000601809

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
IRF3-001	ENSP00000366344 ENST00000377139	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3 M0R205 [Target identity:67%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000472223} M0QYT9 [Target identity:65%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470069} M0QYX3 [Target identity:44%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0QXC8 [Target identity:27%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:24%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R007 [Target identity:23%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} M0R0R8 [Target identity:19%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402} Q71U93 [Target identity:7%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]	427	47.2	No
IRF3-002	ENSP00000471896 ENST00000601291	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3 M0R205 [Target identity:63%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000472223} M0QYX3 [Target identity:42%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0QXC8 [Target identity:26%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:23%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R007 [Target identity:22%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} M0R0R8 [Target identity:18%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402} Q71U93 [Target identity:6%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0009617 [response to bacterium] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032496 [response to lipopolysaccharide] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043330 [response to exogenous dsRNA] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045351 [type I interferon biosynthetic process] GO:0045358 [negative regulation of interferon-beta biosynthetic process] GO:0050689 [negative regulation of defense response to virus by host] GO:0050715 [positive regulation of cytokine secretion] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0060340 [positive regulation of type I interferon-mediated signaling pathway] GO:0071359 [cellular response to dsRNA] GO:0071888 [macrophage apoptotic process] GO:0097300 [programmed necrotic cell death]	452	49.1	No
IRF3-004	ENSP00000469113 ENST00000597198	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3 M0R205 [Target identity:67%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000472223} M0QYT9 [Target identity:65%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470069} M0QYX3 [Target identity:44%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0QXC8 [Target identity:27%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:24%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R007 [Target identity:23%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} M0R0R8 [Target identity:19%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402} Q71U93 [Target identity:7%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]	427	47.2	No
IRF3-005	ENSP00000471358 ENST00000599223	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3 M0R3C2 [Target identity:88%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000473128} M0QYX3 [Target identity:63%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0R007 [Target identity:34%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} Q71U93 [Target identity:10%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]	300	33.2	No
IRF3-006	ENSP00000310127 ENST00000309877	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3 M0R205 [Target identity:67%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000472223} M0QYT9 [Target identity:65%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470069} M0QYX3 [Target identity:44%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0QXC8 [Target identity:27%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:24%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R007 [Target identity:23%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} M0R0R8 [Target identity:19%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402} Q71U93 [Target identity:7%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]	427	47.2	No
IRF3-007	ENSP00000470431 ENST00000600911	M0QZB7 Show all » « Hide M0QZB7 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470431} M0R205 [Target identity:70%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000472223} M0QYX3 [Target identity:46%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0QXC8 [Target identity:29%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R007 [Target identity:25%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} M0R0X9 [Target identity:25%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R0R8 [Target identity:20%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402} Q71U93 [Target identity:7%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated]	408	44.5	No
IRF3-008	ENSP00000470512 ENST00000596765	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]	154	16.7	No
IRF3-009	ENSP00000470069 ENST00000599144	M0QYT9 Show all » « Hide M0QYT9 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470069} M0QXC8 [Target identity:42%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:37%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R0R8 [Target identity:29%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]	281	30.8	No
IRF3-010	ENSP00000472582 ENST00000598808	M0QYT9 Show all » « Hide M0QYT9 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470069} M0QXC8 [Target identity:42%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:37%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R0R8 [Target identity:29%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]	281	30.8	No
IRF3-011	ENSP00000472601 ENST00000593922	M0QYT9 Show all » « Hide M0QYT9 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470069} M0QXC8 [Target identity:42%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:37%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R0R8 [Target identity:29%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]	281	30.8	No
IRF3-012	ENSP00000472700 ENST00000600022	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]	154	16.7	No
IRF3-017	ENSP00000468911 ENST00000596822	M0QX56 Show all » « Hide M0QX56 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000468911}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		135	14	No
IRF3-019	ENSP00000470140 ENST00000601809	M0QYX3 Show all » « Hide M0QYX3 [Target identity:99%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0R007 [Target identity:53%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} Q71U93 [Target identity:15%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005737 [cytoplasm]	191	21.1	No
IRF3-020	ENSP00000470905 ENST00000600453	M0R007 Show all » « Hide M0R007 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} Q71U93 [Target identity:29%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity]	102	11.8	No
IRF3-022	ENSP00000471517 ENST00000593818	M0R0X9 Show all » « Hide M0R0X9 [Target identity:99%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R0R8 [Target identity:79%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]	106	11.5	No
IRF3-023	ENSP00000469067 ENST00000595034	M0QXC8 Show all » « Hide M0QXC8 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:88%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R0R8 [Target identity:70%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]	119	13	No
IRF3-024	ENSP00000471402 ENST00000601373	M0R0R8 Show all » « Hide M0R0R8 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]	84	9.2	No
IRF3-025	ENSP00000473128 ENST00000596756	M0R3C2 Show all » « Hide M0R3C2 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000473128} M0QYX3 [Target identity:71%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0R007 [Target identity:38%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} Q71U93 [Target identity:11%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated]	264	29.2	No
IRF3-027	ENSP00000473176 ENST00000593337	M0R3E9 Show all » « Hide M0R3E9 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000473176} M0R007 [Target identity:66%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} Q71U93 [Target identity:19%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated]	153	17.4	No
IRF3-028	ENSP00000472223 ENST00000598108	M0R205 Show all » « Hide M0R205 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000472223} M0QYX3 [Target identity:66%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0QXC8 [Target identity:41%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:36%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R007 [Target identity:35%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} M0R0R8 [Target identity:29%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402} Q71U93 [Target identity:10%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated]	287	31.8	No
IRF3-201	ENSP00000366339 ENST00000377135	M0QYT9 Show all » « Hide M0QYT9 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470069} M0QXC8 [Target identity:42%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:37%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R0R8 [Target identity:29%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]	281	30.8	No
IRF3-202	ENSP00000400378 ENST00000442265	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3 Q71U93 [Target identity:28%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]	104	12.3	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx