PROZ

GENE INFORMATION

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Gene name

PROZ (HGNC Symbol)

Synonyms

PZ

Description

Protein Z, vitamin K-dependent plasma glycoprotein (HGNC Symbol)

Entrez gene summary

This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Chromosome

13

Cytoband

q34

Chromosome location (bp)

113158654 - 113172383

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000126231 (version 78.38)

Entrez gene

8858

UniProt

P22891 (UniProt - Evidence at protein level)

neXtProt

NX_P22891

Antibodypedia

PROZ antibodies
 

PROTEIN VIEW

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PROZ-001
 
PROZ-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PROZ-001 ENSP00000364697
ENST00000375547
P22891
Show all »
Show » Show » 400 44.7 Yes 0
PROZ-002 ENSP00000344458
ENST00000342783
P22891
Show all »
Show » Show » 422 47.1 Yes 0