FOXA2

GENERAL INFORMATION

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Gene name

FOXA2

Gene description

Forkhead box A2

Protein class

Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lung, stomach)
GTEx:Tissue enhanced (liver, pancreas, stomach)

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
CAB001388
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lung, stomach)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (liver, pancreas, stomach)

Organ

Expression



GENE INFORMATION

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Gene name

FOXA2 (HGNC Symbol)

Synonyms

HNF3B

Description

Forkhead box A2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Chromosome

20

Cytoband

p11.21

Chromosome location (bp)

22581005 - 22585455

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125798 (version 78.38)

Entrez gene

3170

UniProt

Q9Y261 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y261

Antibodypedia

FOXA2 antibodies


PROTEIN BROWSER

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ENST00000377115
 
ENST00000419308
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FOXA2-001 ENSP00000366319
ENST00000377115
Q9Y261
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Show » Show » 457 48.3 No 0
FOXA2-002 ENSP00000400341
ENST00000419308
Q9Y261
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Show » Show » 463 48.9 No 0