CD70

GENE INFORMATION

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Gene name

CD70 (HGNC Symbol)

Synonyms

CD27L, CD27LG, TNFSF7

Description

CD70 molecule (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

6583183 - 6604103

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125726 (version 78.38)

Entrez gene

970

UniProt

P32970 (UniProt - Evidence at protein level)

neXtProt

NX_P32970

Antibodypedia

CD70 antibodies
 

PROTEIN VIEW

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CD70-001
 
CD70-002
 
CD70-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD70-001 ENSP00000245903
ENST00000245903
P32970
Show all »
Show » Show » 193 21.1 No 0
CD70-002 ENSP00000470805
ENST00000597430
M0QZW2
Show all »
Show » 65 7.1 No 1
CD70-003 ENSP00000395294
ENST00000423145
P32970
Show all »
Show » Show » 208 23.4 No 1