HS3ST3B1

GENE INFORMATION

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Gene name

HS3ST3B1 (HGNC Symbol)

Synonyms

30ST3B1, 3OST3B1

Description

Heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a type II integral membrane protein that belongs to the 3-O-sulfotransferases family. These proteins catalyze the addition of sulfate groups at the 3-OH position of glucosamine in heparan sulfate. The substrate specificity of individual members of the family is based on prior modification of the heparan sulfate chain, thus allowing different members of the family to generate binding sites for different proteins on the same heparan sulfate chain. Following treatment with a histone deacetylase inhibitor, expression of this gene is activated in a pancreatic cell line. The increased expression results in promotion of the epithelial-mesenchymal transition. In addition, the modification catalyzed by this protein allows herpes simplex virus membrane fusion and penetration. A very closely related homolog with an almost identical sulfotransferase domain maps less than 1 Mb away. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Chromosome

17

Cytoband

p12

Chromosome location (bp)

14301083 - 14349404

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125430 (version 78.38)

Entrez gene

9953

UniProt

Q9Y662 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y662

Antibodypedia

HS3ST3B1 antibodies
 

PROTEIN VIEW

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HS3ST3B1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HS3ST3B1-001 ENSP00000354213
ENST00000360954
Q9Y662
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