Tissue expression of IRF1 - Summary - The Human Protein Atlas

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IRF1

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	IRF1
Gene description	Interferon regulatory factor 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear and nucleoli expression in several different tissue types.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Data reliability	Supportive based on 2 antibodies. HPA063131 , CAB011662
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	IRF1 (HGNC Symbol)
Synonyms	MAR
Description	Interferon regulatory factor 1 (HGNC Symbol)
Entrez gene summary	IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q31.1
Chromosome location (bp)	132481609 - 132490798
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125347 (version 78.38)
Entrez gene	3659
UniProt	P10914 (UniProt - Evidence at protein level)
neXtProt	NX_P10914
Antibodypedia	IRF1 antibodies

PROTEIN BROWSER

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ENST00000245414		ENST00000405885		ENST00000437654		ENST00000458069		ENST00000476613		ENST00000613424

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
IRF1-001	ENSP00000245414 ENST00000245414	P10914 Show all » « Hide P10914 [Direct mapping] Interferon regulatory factor 1 Q6FHN8 [Target identity:100%; Query identity:100%] IRF1 protein {ECO:0000313\|EMBL:CAG46514.1}; Interferon regulatory factor 1 {ECO:0000313\|EMBL:AAV38560.1}; Interferon regulatory factor-1 {ECO:0000313\|EMBL:ABH05670.1}; cDNA, FLJ94683, Homo sapiens interferon regulatory factor 1 (IRF1), mRNA {ECO:0000313\|EMBL:BAG36735.1} C9JD95 [Target identity:59%; Query identity:100%] Interferon regulatory factor 1 {ECO:0000313\|Ensembl:ENSP00000396318} R4GNI0 [Target identity:36%; Query identity:100%] Interferon regulatory factor 1 {ECO:0000313\|Ensembl:ENSP00000473661} Q75MZ8 [Target identity:12%; Query identity:100%] IRF1 {ECO:0000313\|EMBL:AAB93488.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Disease related genes	Show » « Hide GO:0000790 [nuclear chromatin] GO:0000975 [regulatory region DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002819 [regulation of adaptive immune response] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0007050 [cell cycle arrest] GO:0007596 [blood coagulation] GO:0008285 [negative regulation of cell proliferation] GO:0010468 [regulation of gene expression] GO:0019221 [cytokine-mediated signaling pathway] GO:0032481 [positive regulation of type I interferon production] GO:0032728 [positive regulation of interferon-beta production] GO:0034124 [regulation of MyD88-dependent toll-like receptor signaling pathway] GO:0035458 [cellular response to interferon-beta] GO:0043374 [CD8-positive, alpha-beta T cell differentiation] GO:0043565 [sequence-specific DNA binding] GO:0045084 [positive regulation of interleukin-12 biosynthetic process] GO:0045088 [regulation of innate immune response] GO:0045590 [negative regulation of regulatory T cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051607 [defense response to virus] GO:0051726 [regulation of cell cycle] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071260 [cellular response to mechanical stimulus] GO:2000564 [regulation of CD8-positive, alpha-beta T cell proliferation]	325	36.5	No
IRF1-002	ENSP00000405655 ENST00000437654	C9J9C5 Show all » « Hide C9J9C5 [Target identity:100%; Query identity:100%] Interferon regulatory factor 1 {ECO:0000313\|Ensembl:ENSP00000405655} X5D3F6 [Target identity:100%; Query identity:69%] Interferon regulatory factor {ECO:0000256\|PIRNR:PIRNR038196} R4GNI0 [Target identity:59%; Query identity:100%] Interferon regulatory factor 1 {ECO:0000313\|Ensembl:ENSP00000473661}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0006355 [regulation of transcription, DNA-templated]	198	22.7	No
IRF1-007	ENSP00000473661 ENST00000476613	R4GNI0 Show all » « Hide R4GNI0 [Target identity:100%; Query identity:100%] Interferon regulatory factor 1 {ECO:0000313\|Ensembl:ENSP00000473661}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0000975 [regulatory region DNA binding]	118	13.9	No
IRF1-008	ENSP00000384406 ENST00000405885	P10914 Show all » « Hide P10914 [Direct mapping] Interferon regulatory factor 1 Q6FHN8 [Target identity:100%; Query identity:100%] IRF1 protein {ECO:0000313\|EMBL:CAG46514.1}; Interferon regulatory factor 1 {ECO:0000313\|EMBL:AAV38560.1}; Interferon regulatory factor-1 {ECO:0000313\|EMBL:ABH05670.1}; cDNA, FLJ94683, Homo sapiens interferon regulatory factor 1 (IRF1), mRNA {ECO:0000313\|EMBL:BAG36735.1} C9JD95 [Target identity:59%; Query identity:100%] Interferon regulatory factor 1 {ECO:0000313\|Ensembl:ENSP00000396318} R4GNI0 [Target identity:36%; Query identity:100%] Interferon regulatory factor 1 {ECO:0000313\|Ensembl:ENSP00000473661} Q75MZ8 [Target identity:12%; Query identity:100%] IRF1 {ECO:0000313\|EMBL:AAB93488.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Disease related genes	Show » « Hide GO:0000790 [nuclear chromatin] GO:0000975 [regulatory region DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002819 [regulation of adaptive immune response] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0007050 [cell cycle arrest] GO:0007596 [blood coagulation] GO:0008285 [negative regulation of cell proliferation] GO:0019221 [cytokine-mediated signaling pathway] GO:0032481 [positive regulation of type I interferon production] GO:0032728 [positive regulation of interferon-beta production] GO:0034124 [regulation of MyD88-dependent toll-like receptor signaling pathway] GO:0035458 [cellular response to interferon-beta] GO:0045088 [regulation of innate immune response] GO:0045590 [negative regulation of regulatory T cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0051607 [defense response to virus] GO:0051726 [regulation of cell cycle] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071260 [cellular response to mechanical stimulus] GO:2000564 [regulation of CD8-positive, alpha-beta T cell proliferation]	325	36.5	No
IRF1-010	ENSP00000396318 ENST00000458069	C9JD95 Show all » « Hide C9JD95 [Target identity:100%; Query identity:100%] Interferon regulatory factor 1 {ECO:0000313\|Ensembl:ENSP00000396318} R4GNI0 [Target identity:61%; Query identity:100%] Interferon regulatory factor 1 {ECO:0000313\|Ensembl:ENSP00000473661}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0000975 [regulatory region DNA binding]	192	21.9	No
IRF1-201	ENSP00000480887 ENST00000613424	V9P921 Show all » « Hide V9P921 [Target identity:100%; Query identity:100%] Interferon regulatory factor 1 isoform d78 {ECO:0000313\|EMBL:AGV15458.1} R4GNI0 [Target identity:58%; Query identity:100%] Interferon regulatory factor 1 {ECO:0000313\|Ensembl:ENSP00000473661}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0000975 [regulatory region DNA binding]	201	22.8	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx