SPDEF

GENE INFORMATION

? »

Gene name

SPDEF (HGNC Symbol)

Synonyms

bA375E1.3, PDEF

Description

SAM pointed domain containing ETS transcription factor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

6

Cytoband

p21.31

Chromosome location (bp)

34537802 - 34556333

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124664 (version 78.38)

Entrez gene

25803

UniProt

O95238 (UniProt - Evidence at protein level)

neXtProt

NX_O95238

Antibodypedia

SPDEF antibodies
 

PROTEIN VIEW

? »
 
 
 
SPDEF-001
 
SPDEF-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPDEF-001 ENSP00000363149
ENST00000374037
O95238
Show all »
Show » Show » 335 37.5 No 0
SPDEF-201 ENSP00000442715
ENST00000544425
O95238
Show all »
Show » Show » 319 35.7 No 0