WRNIP1

GENE INFORMATION

? »

Gene name

WRNIP1 (HGNC Symbol)

Synonyms

bA420G6.2, FLJ22526, WHIP

Description

Werner helicase interacting protein 1 (HGNC Symbol)

Entrez gene summary

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

Chromosome

6

Cytoband

p25.2

Chromosome location (bp)

2765414 - 2786952

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124535 (version 78.38)

Entrez gene

56897

UniProt

Q96S55 (UniProt - Evidence at protein level)

neXtProt

NX_Q96S55

Antibodypedia

WRNIP1 antibodies
 

PROTEIN VIEW

? »
 
 
 
WRNIP1-001
 
WRNIP1-002
 
WRNIP1-003
 
WRNIP1-004
 
WRNIP1-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

WRNIP1-001 ENSP00000370150
ENST00000380773
Q96S55
Show all »
Show » Show » 665 72.1 No 0
WRNIP1-002 ENSP00000370148
ENST00000380771
Q96S55
Show all »
Show » Show » 640 69.5 No 0
WRNIP1-003 ENSP00000370146
ENST00000380769
Q96S55
Show all »
Show » Show » 445 49.6 No 0
WRNIP1-004 ENSP00000370141
ENST00000380764
Q96S55
Show all »
Show » Show » 281 31.3 No 0
WRNIP1-201 ENSP00000477551
ENST00000618555
Q96S55
Show all »
Show » Show » 665 72.1 No 0