GRM4

GENE INFORMATION

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Gene name

GRM4 (HGNC Symbol)

Synonyms

GPRC1D, mGlu4, MGLUR4

Description

Glutamate receptor, metabotropic 4 (HGNC Symbol)

Entrez gene summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Chromosome

6

Cytoband

p21.31

Chromosome location (bp)

34018645 - 34155622

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124493 (version 78.38)

Entrez gene

2914

UniProt

Q14833 (UniProt - Evidence at protein level)

neXtProt

NX_Q14833

Antibodypedia

GRM4 antibodies
 

PROTEIN VIEW

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GRM4-001
 
GRM4-002
 
GRM4-003
 
GRM4-004
 
GRM4-005
 
GRM4-011
 
GRM4-201
 
GRM4-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRM4-001 ENSP00000440556
ENST00000538487
Q14833
Show all »
Show » Show » 912 101.9 Yes 7
GRM4-002 ENSP00000363292
ENST00000374177
Q14833
Show all »
Show » Show » 796 88.5 No 7
GRM4-003 ENSP00000437730
ENST00000544773
Q14833
Show all »
Show » Show » 743 83.6 No 7
GRM4-004 ENSP00000477466
ENST00000609222
Q14833
Show all »
Show » Show » 779 87.4 No 7
GRM4-005 ENSP00000398456
ENST00000455714
Q14833
Show all »
Show » Show » 772 86.7 No 7
GRM4-011 ENSP00000476561
ENST00000609443
V9GYB0
Show all »
Show » Show » 96 11.1 No 0
GRM4-201 ENSP00000363296
ENST00000374181
B7ZLU9
Show all »
Show » Show » 865 96.1 Yes 7
GRM4-202 ENSP00000437925
ENST00000535756
Q14833
Show all »
Show » Show » 779 87.4 No 7