PLCG1

GENERAL INFORMATION

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Gene name

PLCG1

Gene description

Phospholipase C, gamma 1

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA036681 , HPA036682 , CAB004277
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PLCG1 (HGNC Symbol)

Synonyms

NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1

Description

Phospholipase C, gamma 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q12

Chromosome location (bp)

41136960 - 41196787

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124181 (version 78.38)

Entrez gene

5335

UniProt

P19174 (UniProt - Evidence at protein level)

neXtProt

NX_P19174

Antibodypedia

PLCG1 antibodies


PROTEIN BROWSER

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ENST00000244007
 
ENST00000373271
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLCG1-005 ENSP00000362368
ENST00000373271
P19174
Show all »
Show » Show » 1290 148.5 No 0
PLCG1-013 ENSP00000244007
ENST00000244007
P19174
Show all »
Show » Show » 1291 148.7 No 0