SLPI

GENERAL INFORMATION

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Gene name

SLPI

Gene description

Secretory leukocyte peptidase inhibitor

Protein class

Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Group enriched (cervix, uterine, salivary gland)

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic expression in respiratory epithelial cells, renal tubules, glandular cells in cervix, fallopian tube and seminal vesicle.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA027774 , CAB002303
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cervix, uterine, salivary gland)

Organ

Expression



GENE INFORMATION

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Gene name

SLPI (HGNC Symbol)

Synonyms

ALK1, ALP, BLPI, HUSI, HUSI-I, WAP4, WFDC4

Description

Secretory leukocyte peptidase inhibitor (HGNC Symbol)

Entrez gene summary

This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

45252239 - 45254564

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124107 (version 78.38)

Entrez gene

6590

UniProt

P03973 (UniProt - Evidence at protein level)

neXtProt

NX_P03973

Antibodypedia

SLPI antibodies


PROTEIN BROWSER

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ENST00000338380
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLPI-001 ENSP00000342082
ENST00000338380
P03973
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