PFKFB2

GENE INFORMATION

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Gene name

PFKFB2

Synonyms

Description

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q32.1

Chromosome location (bp)

207034366 - 207081024

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123836 (version 78.38)

Entrez gene

5208

UniProt

O60825 (UniProt - Evidence at protein level)

neXtProt

NX_O60825

Antibodypedia

PFKFB2 antibodies
 

PROTEIN VIEW

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PFKFB2-001
 
PFKFB2-002
 
PFKFB2-009
 
PFKFB2-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PFKFB2-001 ENSP00000356047
ENST00000367080
O60825
Show all »
Show » Show » 505 58.5 No 0
PFKFB2-002 ENSP00000356046
ENST00000367079
O60825
Show all »
Show » Show » 471 54.4 No 0
PFKFB2-009 ENSP00000484988
ENST00000618513
Show » 49 5.4 No 0
PFKFB2-010 ENSP00000439420
ENST00000545806
Show » Show » 125 14.3 No 0