CDKN2C

GENE INFORMATION

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Gene name

CDKN2C (HGNC Symbol)

Synonyms

INK4C, p18

Description

Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p32.3

Chromosome location (bp)

50960745 - 50974633

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123080 (version 78.38)

Entrez gene

1031

UniProt

P42773 (UniProt - Evidence at protein level)

neXtProt

NX_P42773

Antibodypedia

CDKN2C antibodies
 

PROTEIN VIEW

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CDKN2C-001
 
CDKN2C-002
 
CDKN2C-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDKN2C-001 ENSP00000262662
ENST00000262662
P42773
Show all »
Show » Show » 168 18.1 No 0
CDKN2C-002 ENSP00000360826
ENST00000371761
P42773
Show all »
Show » Show » 168 18.1 No 0
CDKN2C-201 ENSP00000379452
ENST00000396148
P42773
Show all »
Show » Show » 168 18.1 No 0