CRY2

GENE INFORMATION

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Gene name

CRY2

Synonyms

Description

Cryptochrome circadian clock 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Chromosome

11

Cytoband

p11.2

Chromosome location (bp)

45847118 - 45883248

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121671 (version 78.38)

Entrez gene

1408

UniProt

Q49AN0 (UniProt - Evidence at protein level)

neXtProt

NX_Q49AN0

Antibodypedia

CRY2 antibodies
 

PROTEIN VIEW

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CRY2-001
 
CRY2-002
 
CRY2-011
 
CRY2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CRY2-001 ENSP00000406751
ENST00000443527
B4DZD6
Show all »
Show » Show » 614 68.9 Yes 0
CRY2-002 ENSP00000397419
ENST00000417225
Q49AN0
Show all »
Show » Show » 532 60.6 No 0
CRY2-011 ENSP00000484684
ENST00000616080
Q49AN0
Show all »
Show » Show » 593 66.9 Yes 0
CRY2-201 ENSP00000478187
ENST00000616623
B4DZD6
Show all »
Show » Show » 614 68.9 Yes 0