CSTA

GENE INFORMATION

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Gene name

CSTA (HGNC Symbol)

Synonyms

STF1, STFA

Description

Cystatin A (stefin A) (HGNC Symbol)

Entrez gene summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q21.1

Chromosome location (bp)

122325244 - 122341972

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121552 (version 78.38)

Entrez gene

1475

UniProt

P01040 (UniProt - Evidence at protein level)

neXtProt

NX_P01040

Antibodypedia

CSTA antibodies
 

PROTEIN VIEW

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CSTA-001
 
CSTA-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CSTA-001 ENSP00000264474
ENST00000264474
P01040
Show all »
Show » Show » 98 11 No 0
CSTA-002 ENSP00000418891
ENST00000479204
C9J0E4
Show all »
Show » Show » 63 7.1 No 0