IAPP

GENE INFORMATION

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Gene name

IAPP (HGNC Symbol)

Synonyms

AMYLIN, DAP, IAP

Description

Islet amyloid polypeptide (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]

Chromosome

12

Cytoband

p12.1

Chromosome location (bp)

21354959 - 21379978

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121351 (version 78.38)

Entrez gene

3375

UniProt

P10997 (UniProt - Evidence at protein level)

neXtProt

NX_P10997

Antibodypedia

IAPP antibodies
 

PROTEIN VIEW

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IAPP-001
 
IAPP-002
 
IAPP-003
 
IAPP-004
 
IAPP-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IAPP-001 ENSP00000240652
ENST00000240652
P10997
Show all »
Show » Show » 89 9.8 Yes 0
IAPP-002 ENSP00000445711
ENST00000542023
F5H1F0
Show all »
Show » 79 9 Yes 0
IAPP-003 ENSP00000445980
ENST00000537593
F5H0S1
Show all »
Show » Show » 79 8.6 Yes 0
IAPP-004 ENSP00000437559
ENST00000535428
Show » Show » 85 9.4 No 0
IAPP-005 ENSP00000437357
ENST00000539393
P10997
Show all »
Show » Show » 89 9.8 Yes 0