LRAT

GENERAL INFORMATION

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Gene name

LRAT

Gene description

Lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (small intestine, thyroid gland)
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

RNA-based expert annotation could not be performed.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA008397
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (small intestine, thyroid gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

LRAT (HGNC Symbol)

Synonyms

LCA14

Description

Lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Chromosome

4

Cytoband

q32.1

Chromosome location (bp)

154626945 - 154753118

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121207 (version 78.38)

Entrez gene

9227

UniProt

O95237 (UniProt - Evidence at protein level)

neXtProt

NX_O95237

Antibodypedia

LRAT antibodies


PROTEIN BROWSER

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ENST00000336356
 
ENST00000502525
 
ENST00000507827
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LRAT-002 ENSP00000422324
ENST00000502525
D6RC94
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Show » 69 7.8 Yes 0
LRAT-004 ENSP00000426761
ENST00000507827
O95237
Show all »
Show » Show » 230 25.7 Yes 1
LRAT-005 ENSP00000337224
ENST00000336356
O95237
Show all »
Show » Show » 230 25.7 Yes 1